「ヒューマン・
オルガノイド」
プロジェクト

2023年

2023.11

【論文】Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley H-A, Zhang X, Sundaram N, Hudson J-R, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence J-R, Hachimi M, North T, Daley GQ, Mayhew CN, Hu Y-C, Takebe T, Helmrath M, Wells JM.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon.
(2023) Cell Stem Cell, 30(11):1434-1451.e9.
DOI: https://doi.org/10.1016/j.stem.2023.10.002

2023.10

【論文】Al Reza, H, Farooqui Z, Al Reza A, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T.
Synthetic Augmentation of Bilirubin Metabolism in Human Pluripotent Stem Cell-derived Liver Organoids.
(2023). Stem Cell Rep, 18 (11), 2071-2083.
DOI: https://doi.org/10.1016/j.stemcr.2023.09.006

【論文】Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen C-T, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T*.
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.
(2023). Cell Stem Cell, (30) 1315–1330.
DOI: https://doi.org/10.1016/j.stem.2023.09.001

2023.07

【発表】武部貴則, 造血性肝臓オルガノイドを用いた血液疾患研究への展開, 埼玉県小児血液同好会

【発表】武部貴則, 器官機能再建への展望, 第32回日本腎泌尿器疾患予防医学研究会

【発表】Takebe T, Promise and Impact of Organoid Medicine, AMED-SCN Showcase Event 2023

【発表】Takebe T, Developmental Origin of the Liver, Society for Developmental Biology (SDB) 2023 annual meeting

2023.06

【論文】Matsuzaki T*, Shimokawa Y, Koike H, Kimura M, Kawano Y, Okuma N, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi A-I, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T*, and Yoshikawa H-Y*. (2023).
Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells.
STAR protocols 4 (3), 102471
DOI： https://doi.org/10.1016/j.xpro.2023.102471

2023.05

【発表】Takebe T, Modeling Hepato-biliary-pancreatic Organogenesis in a Dish, The 87th Cold Spring Harbor Laboratory Symposium on Quantitative Biology - Stem Cells

2023.04

【論文】Tamaoki N, Siebert S, Maeda T, Ha N-H, Good M-L, Huang Y, Vodnala S-K, Haro-Mora J-J, Uchida N, Tisdale J-F, Sweeney C-L, Choi U, Brault J, Koontz S, Malech H, Yamazaki Y, Isonaka R, Goldstein D, Kimura M, Takebe T, Zou J, Stroncek D, Robey P-G, Kruhlak M, Restifo N, Vizcardo R. (2023).
Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells
Cell Rep Methods, 3(4), 100460
DOI: https://doi.org/10.1016/j.crmeth.2023.100460

【発表】武部貴則, オルガノイドを用いた器官創生への展望, 第31回日本医学会総会, 東京国際フォーラム

2023.03

【論文】Kang, S.Y., Kimura, M., Shrestha, S., Lewis, P., Lee, S.J., Cai, Y., Joshi, P., Acharya, P., Liu, J., Yang, Y., Sanchez, J.G., Ayyagari, S., Alsberg, E., Wells, J.M.*, Takebe, T.*, and Lee, M.Y.*. (2023).
A pillar and perfusion plate platform for robust human organoid culture and analysis, Adv. Healthcare Mater., 2302502
DOI: https://doi.org/10.1101/2023.03.11.532210

【論文】Fujii T, Yoneyama Y, Kinebuchi A, Ozeki N, Maeda S, Saiki N, Fengshi Chen-Yoshikawa T, Date H, Nishiwaki K, Takebe T*. (2023).
Enteral liquid ventilation oxygenates a hypoxic pig model.
iScience, 26(3):106142
DOI: https://doi.org/10.1016/j.isci.2023.106142