「ヒューマン・
オルガノイド」
プロジェクト

2025年

2025.03

【発表】武部貴則. 肝機能置換へ向けたオルガノイド技術の新展開, 第24回日本再生医療学会総会, 2025/3/22

【発表】武部貴則. 肝胆膵機能再建への展望, 第52回 日本膵・膵島移植学会, 2025/3/8

【論文】Ashmore-Harris C, Ayabe H, Yoshizawa E, Arisawa T, Takada Y, Takebe T, Fruhwirth G-O, Gene editing enables non-invasive in vivo PET imaging of human induced pluripotent stem cell derived liver bud organoids. Molecular Therapy - Methods & Clinical Development, 2025, 101406.
DOI: https://doi.org/10.1016/j.omtm.2025.101406

2025.02

【論文】Liu YJ, Kimura M, Li X, Sulc J, Wang Q, Rodríguez-López S, Scantlebery AML, Strotjohann K, Gallart-Ayala H, Vijayakumar A, Myers RP, Ivanisevic J, Houtkooper RH, Subramanian GM, Takebe T, Auwerx J. (2024) ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH. J Hepatol. 22:S0168-8278(24)02484-X. PMID: 39181211
DOI: https://doi.org/10.1016/j.jhep.2024.08.009

2025.01

【発表】武部貴. Happiness-driven Approach：ウェルビーイングへの可能性, 第13回日本公衆衛生看護学会学術集会, 2025/1/4

【論文】Yoneyama Y. Zhang R-R, Maezawa M, Kimura M, Cai Y, Adam M, Parameswaran S, Masaki H, Mizuno N, Bhadury J, Maezawa S, Ochiai H, Nakauchi H, Potter S, Weirauch M, Takebe T. Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State, Proc Natl Acad Sci U S A, 122 (4) e2413351122.
DOI: https://doi.org/10.1073/pnas.2413351122

【論文】Murata N, Nishii S, Usuha R, Kodaka A, Fujimori M, Sugawara H, Kiriyama T, Uchikado H, Okumura Y, Takebe T. A Gamified N-back App for Identifying Mild-cognitive Impairment in Older Adults. JMA J. 2025;8(1):174-182
DOI: https://doi.org/10.31662/jmaj.2024-0217

2024年

2024.12

【発表】T Takebe. Promise and Impact of Organoid Medicine, 16th US-JAPAN DDS SYMPOSIUM, 2024/12/19

【論文】Tominaga K, Kechele DO, Sanchez JG, Vales S, Jurickova I, Roman L, Asai A, Enriquez JR, McCauley HA, Kishimoto K, Iwasawa K, Singh A, Horio Y, Múnera JO, Takebe T, Zorn AM, Helmrath MA, Denson LA, Wells JM. (2024) Deriving human intestinal organoids with functional tissue-resident macrophages all from pluripotent stem cells. Cell Mol Gastroenterol Hepatol, 101444.
DOI: https://doi.org/10.1016/j.jcmgh.2024.101444

2024.11

【発表】武部貴則. My Medicine～100億人100億通りの自己実現に向けて～, 第11回日本地域理学療法学術大会, 2024/11/16

【発表】武部貴則. 肝胆膵臓領域におけるオルガノイド工学の可能性, 国際バイオファブリケーション学会, 2024/11/13

【発表】武部貴則. 肝疾患を対象としたオルガノイド医療の展望, 第50回日本臓器保存生物医学会学術集会, 2024/11/8

【発表】武部貴則. オルガノイド医学の適応修復研究への展開, 第97回日本生化学会大会, 2024/11/7

2024.10

【発表】武部貴則．ストリートメディカル ー 生活の現場へ繋がる医療, 第83回日本公衆衛生学会総会, 2024/10/30

【論文】Polling H, Sundaram N, Fisher G, Shiley J, Singh A-J, Cortez A, Wells J-M, Mayhew C, Takebe T, Mahe M, Helmrath M*: Human pluripotent stem cell derived organoids regenerate damaged bowel in vivo. (2024) Cell Stem Cell, 31 (10), 1513-1523. e7.
DOI: https://doi.org/10.1016/j.stem.2024.08.009

2024.09

【発表】T Takebe. Organoid based Therapeutics for the Management of Liver Failure, India Liver cancer conference in India, 2024/9/28

【受賞】Takanori Takebe. イグ・ノーベル賞（生理学賞）, The Nobel Foundation, USA, 2024/9/12

2024.08

【発表】T Takebe. Organoid Medicine for Hepatology, KSSCR, 2024/8/30

2024.07

【発表】武部貴則. オルガノイド医療の新展開, 日本外科代謝栄養学会第61回学術集会 ,2024/7/26

【論文】Sheth M, Sharma M, Lehn M, Reza HA, Takebe T, Takiar V, Wise-Draper T, Esfandiari L. (2024) Three-dimensional matrix stiffness modulates mechanosensitive and phenotypic alterations in oral squamous cell carcinoma spheroids. APL BioEng. 31;8(3):036106.
DOI: https://doi.org/10.1063/5.0210134

2024.06

【発表】武部貴則. オルガノイド研究の可能性ーヒト全層皮膚の人為的再構成, 第49回日本香粧品学会学術大会, 2024/6/29

【発表】武部貴則, 腸換気（EVA）メカニズムを応用した呼吸不全治療, 日本麻酔科学会 第71 回学術集会, 2024/6/6

【受賞】武部貴則. 神戸賞（Young Investigator賞）. 中谷財団. 2024/6/1

2024.05

【発表】武部貴則, ヒューマンオルガノイドを用いた代謝疾患研究, 第67回日本糖尿病学会年次学術集会, 2024/5/19

【発表】武部貴則. 多様性iPS細胞パネルを用いた疾患個体差研究の可能性, 第125回日本耳鼻咽喉科頭頸部外科学会総会, 2024/5/16

2024.04

【発表】武部貴則. iPS細胞ｘオルガノイド‐ 疾患多様性の理解へ. 第64回日本呼吸器学会学術講演会, 2024/4/6

【受賞】Takanori Takebe. 2024 Vilcek Prize for Creative Promise. Vilcek Foundation. 2024/4/4

2024.03

【受賞】日本再生医療学会　学会賞 （基礎部門）2024/3

2024.01

【論文】Naraoka, Y., Y. Mabuchi, M. Kiuchi, K. Kumagai, D. Hisamatsu, Y. Yoneyama, T. Takebe & C. Akazawa (2024) Quality Control of Stem Cell-Based Cultured Meat According to Specific Differentiation Abilities. Cells, 13, 135.
DOI: https://doi.org/10.3390/cells13020135 .

2023年

2023.11

【論文】Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley H-A, Zhang X, Sundaram N, Hudson J-R, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence J-R, Hachimi M, North T, Daley GQ, Mayhew CN, Hu Y-C, Takebe T, Helmrath M, Wells JM.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon.
(2023) Cell Stem Cell, 30(11):1434-1451.e9.
DOI: https://doi.org/10.1016/j.stem.2023.10.002

2023.10

【論文】Al Reza, H, Farooqui Z, Al Reza A, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T.
Synthetic Augmentation of Bilirubin Metabolism in Human Pluripotent Stem Cell-derived Liver Organoids.
(2023). Stem Cell Rep, 18 (11), 2071-2083.
DOI: https://doi.org/10.1016/j.stemcr.2023.09.006

【論文】Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen C-T, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T*.
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.
(2023). Cell Stem Cell, (30) 1315–1330.
DOI: https://doi.org/10.1016/j.stem.2023.09.001

2023.07

【発表】武部貴則, 造血性肝臓オルガノイドを用いた血液疾患研究への展開, 埼玉県小児血液同好会

【発表】武部貴則, 器官機能再建への展望, 第32回日本腎泌尿器疾患予防医学研究会

【発表】Takebe T, Promise and Impact of Organoid Medicine, AMED-SCN Showcase Event 2023

【発表】Takebe T, Developmental Origin of the Liver, Society for Developmental Biology (SDB) 2023 annual meeting

2023.06

【論文】Matsuzaki T*, Shimokawa Y, Koike H, Kimura M, Kawano Y, Okuma N, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi A-I, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T*, and Yoshikawa H-Y*. (2023).
Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells.
STAR protocols 4 (3), 102471
DOI： https://doi.org/10.1016/j.xpro.2023.102471

2023.05

【発表】Takebe T, Modeling Hepato-biliary-pancreatic Organogenesis in a Dish, The 87th Cold Spring Harbor Laboratory Symposium on Quantitative Biology - Stem Cells

2023.04

【論文】Tamaoki N, Siebert S, Maeda T, Ha N-H, Good M-L, Huang Y, Vodnala S-K, Haro-Mora J-J, Uchida N, Tisdale J-F, Sweeney C-L, Choi U, Brault J, Koontz S, Malech H, Yamazaki Y, Isonaka R, Goldstein D, Kimura M, Takebe T, Zou J, Stroncek D, Robey P-G, Kruhlak M, Restifo N, Vizcardo R. (2023).
Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells
Cell Rep Methods, 3(4), 100460
DOI: https://doi.org/10.1016/j.crmeth.2023.100460

【発表】武部貴則, オルガノイドを用いた器官創生への展望, 第31回日本医学会総会, 東京国際フォーラム

2023.03

【論文】Kang, S.Y., Kimura, M., Shrestha, S., Lewis, P., Lee, S.J., Cai, Y., Joshi, P., Acharya, P., Liu, J., Yang, Y., Sanchez, J.G., Ayyagari, S., Alsberg, E., Wells, J.M.*, Takebe, T.*, and Lee, M.Y.*. (2023).
A pillar and perfusion plate platform for robust human organoid culture and analysis, Adv. Healthcare Mater., 2302502
DOI: https://doi.org/10.1101/2023.03.11.532210

【論文】Fujii T, Yoneyama Y, Kinebuchi A, Ozeki N, Maeda S, Saiki N, Fengshi Chen-Yoshikawa T, Date H, Nishiwaki K, Takebe T*. (2023).
Enteral liquid ventilation oxygenates a hypoxic pig model.
iScience, 26(3):106142
DOI: https://doi.org/10.1016/j.isci.2023.106142