R&D Facilities

Nano-lattice control project

Nano-lattice control project
The purpose of this project is to improce the device performances and to establish the manufacturing tecnology of the high density thin film capacitors for the mobile electronics. Our approach is based on the release, transfer and bonding process that is mainly for the minituarization, high-performance and weight reduction.
The final goal of this project is for the preparation of the high-performance capacitors and its application to device packaging using the nano-scale matching and mismatching of the crystal lattice, that is also leading to the macro-scale phenomena like release, transfer and bonding.

Presto Project leader: Masaaki ICHIKI, Dr.Sci., (Associate Professor in the University of Tokyo)

Displaying 3D Contents into Free Space Project

The mechanism behind the existing 3D display creates a quasi 3D image on 2D space by taking advantage of human binocular disparity. Yet this led to problems such as restriction of eyesight and physiological discomfort. In order to overcome these problems, this project aims to develop a device for "3D display with real imagery" which allows us to view 3D images in a real 3D space.
This device will be able to project 3D images comparable to when high-tech devices appear in science fiction movies by forming dot array in the air while three-dimensionally controlling the focal point of the laser beam which utilizes plasma emission.

ATP Synthesis Regulation

ATP(adenosine-triphosphate) is a general energy coin in the biological world. Demand for ATP production in the cell is varying depending on biological activity, body conditions and environments. There should be yet unknown system in the cell to control the rate of ATP production. Most ATP in the cell is produced by an enzyme called ATP synthase in mitochondria that has been known as a rotary motor molecule. Therefore, regulation of ATP synthesis is to know about the accelerator and the brake of the rotor rotation of ATP synthase. In this project, it is studied with biochemistry, protein science, genetic approach, single molecule observation, and single molecule manipulation. In addition, the study includes the scope on diseases that could be caused from failure of the control of ATP production.We are collaborating with the researchers in New Zealand.

Robotic Operating System Project

Research on Realtime Parallel Dependable Operating System with Realtime Networking Function: This research aims to develop an dependable operating system that has realtime, reliability, safety, and maintenance availability functions for robotics application. The system will be designed and implemented by following P-Bus architecture that is proposed and under developing in CREST Dependable OS project. For this purpose, ART-Linux that we have been developed in last 10 years will be rewritten. An asymmetric multi-processing and realtime ethernet communication functions will be developed. We will open this OS and investigate by applying our robots including humanoid robot project, RT-middleware project, and several company projects.

Project of technological development of generating human disease models of genetically engineered mice fastest in the world for the acceleration of medical and pharmaceutical research.

ES chimera mice for conditional gene targeting.

"SCOT (Speed Conditional Gene Targeting)A System for preparing genetically modified mice within half a year."

Genetically modified mice are valuable as models of human diseases、and they are currently indispensable analytical tools for the development of new drugs. It is vital that the gene-targeting mouse of the relevant gene is obtained as soon as possible since it influences the initial progress of the development of a drug.

Various steps are needed when generating a gene-targeting mouse. It usually takes a long time. Unfortunately、failure is often the result because of the complexity of the steps. The failure rate particularly increases in tissue/organ specific deletion. Therefore、producing conditional gene-targeting mice in a short period of time using a reliable method is desirable.

Our laboratory is mainly working on cardiovascular research using genetically-engineered mice as the main research tools. We have developed original materials and techniques for gene-targeting. We have invented a method for establishing a conditional gene-targeting mouse within half a year through the systematic combination of these materials and technologies. We named this system Speed Conditional Gene Targeting (abbreviation: SCOT). The value of SCOT will be immense in the research and development of new drugs.

Prof. Takayuki Shindo、M.D.、Ph.D.

Shinshu University Graduate School of Medicine

Our homepage URL

http://www7a.biglobe.ne.jp/~shindo/